Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to µ-opioid receptors. In animal models, M1 is up to 6 times more potent than tramadol in producing analgesia and 200 times more potent in µ-opioid binding. Tramadol-induced analgesia is only partially antagonized by the opiate antagonist naloxone in several animal tests. The relative contribution of both tramadol and M1 to human analgesia is dependent upon the plasma concentrations of each compound (see CLINICAL PHARMACOLOGY , Pharmacokinetics ).

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ultracet medication	20	465	kissy 03 Oct 2005 21 : 17	jackshiels 20 Jun 2005 07 : 07
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is ultracet a narcotic	17	243	Nikita 17 Sep 2005 19 : 10	KissOfDeath 23 Jan 2005 17 : 05
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ultracet medication	15	778	webcamconcepts 11 Feb 2005 11 : 16	ze3lock 21 Mar 2005 05 : 08
ultracet dosage	20	445	Island 23 Dec 2005 04 : 21	hawkeye 10 Mar 2005 11 : 04

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